On 5 November 2026, the European Union’s Scientific Committee for Consumer Safety (SCCS) published new Scientific Advice, open for comments, on the safety of Phytonadione Epoxide, namely Vitamin K1 oxide, (CAS No. 25486-55-9).
The deadline for comments is 11 January 2027. Stakeholders can submit their comments or ask for clarifications following the instructions here.
Phytonadione Epoxide (Vitamin K1 oxide) and its cosmetic functions
Phytonadione Epoxide, also known as Vitamin K1 oxide, is an oxidised form of vitamin K1 (phytonadione) that can occur naturally or be produced synthetically.
In cosmetics, it is mainly used as a skin-conditioning ingredient, particularly in eye contour creams, anti-ageing serums, and products intended for sensitive or redness-prone skin. Its use in these formulations is linked to its reported ability to help reduce the appearance of dark circles and redness and promote a more even-looking skin tone.
Phytonadione Epoxide emerged as an alternative to Phytonadione (Vitamin K1) following the latter’s ban in cosmetic products.
However, concerns have emerged in recent years regarding its skin-sensitising potential. Several cases of allergic contact dermatitis have been reported following the use of cosmetic products containing the substance, particularly eye contour products. These reports include serious skin reactions as well as photo-induced reactions.
SCCS preliminary assessment
Based on the information available and the scientific evidence assessed, the SCCS considers Phytonadione Epoxide not safe for use in cosmetic products at concentrations of up to 1%.
At the same time, the available data are not sufficient for the SCCS to establish an alternative concentration at which the ingredient could be considered safe.
Do you have questions on compliance and market access? Contact us here or at coslaw@obelis.net.
References
SCCS. (2026). Scientific Advice on the safety of Phytonadione Epoxide (Vitamin K1 oxide). Retrieved on 5 November 2026.
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